Validated Spectrophotometric Method for Simultaneous Estimation of Atorvastatin and Nicotinic acid in Combined Pharmaceutical dosage form
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چکیده
A simple, precise and cost effective spectrophotometric method have been developed for the estimation Atorvastatin and Nicotinic acid in combination in tablet dosage form by UV spectroscopy, using multi-component mode of analysis. Methanol used as solvent λmax of Atorvastatin and Nicotinic acid was found to be 248nm and 261.5nm respectively. The method shows linearity in the Atorvastatin and Nicotinic acid the Beer-Lamberts concentration range was found to be 2-12 μg/ mL and10 – 60 μg/ mL respectively.The proposed methods are found to be free from interference of excipients and are successfully applied to estimation of the amount of Atorvastatin and Nicotinic acid in bulk and pharmaceutical dosage forms.
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تاریخ انتشار 2012